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Core Faculty

Jeffrey Bryan, DVM, Ph.D.

Associate Professor

Office: 900 East Campus Drive

Phone: 882-7821

Email: bryanjn@missouri.edu

Lab URL:

Home Department: Department of Veterinary Medicine & Surgery

Concentration: Biomedical Informatics

Education: PhD, University of Missouri

Dr. Bryan’s research focuses on comparative examination of cancers in companion animals to better understand cancers in all species. Bryan is an associate professor of veterinary oncology and director of the Comparative Oncology and Epigenetics Laboratory. His particular areas of interest are targeted imaging and therapy and epigenetics of cancer. Targeted imaging and therapy agents take advantage of particular properties of cancer to deliver an imaging or therapy payload to tumors. Bryan is leading research projects studying an immunotherapy agent targeted to the low-oxygen environment of cancer, an herbal derivative that targets iron in tumors, and a nanoparticle chemotherapy targeted to the lymphatic drainage of cancer. The agents under evaluation are destined for use in both dogs and humans to treat lymphomas as well as solid tumors like sarcomas, head and neck cancer, and breast cancer. Each of these trials is designed to develop an approach that is less toxic and more effective than our current cancer treatments.  Epigenetics is the study of mechanisms that change expression of genes critical to cell growth without changing the DNA sequence by mutation. DNA methylation can cause the complete silencing of genes that act as brakes on cell division without any mutation to the gene itself. Unlike mutations, which are permanent changes to the DNA, methylation can be reversed, and the gene can function again, putting the brakes back on cell growth. Dr. Bryan and his team are investigating epigenetic causes and contributions to animal cancers to assist in identifying the most biologically relevant changes in human cancers by comparison.

Selected Publications

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2016

Attali, D; Bidshahri, R; Haynes, C; Bryan, J

ddpcr: an R package and web application for analysis of droplet digital PCR data (Journal Article)

F1000Res, 5 , pp. 1411, 2016, ISSN: 2046-1402 (Linking).

(Links | BibTeX)

Barbour, J A; Howe, P R; Buckley, J D; Bryan, J; Coates, A M

Cerebrovascular and cognitive benefits of high-oleic peanut consumption in healthy overweight middle-aged adults (Journal Article)

Nutr Neurosci, pp. 1-8, 2016, ISSN: 1476-8305 (Electronic) 1028-415X (Linking).

(Links | BibTeX)

Bidshahri, R; Attali, D; Fakhfakh, K; McNeil, K; Karsan, A; Won, J R; Wolber, R; Bryan, J; Hughesman, C; Haynes, C

Quantitative Detection and Resolution of BRAF V600 Status in Colorectal Cancer Using Droplet Digital PCR and a Novel Wild-Type Negative Assay (Journal Article)

J Mol Diagn, 18 (2), pp. 190-204, 2016, ISSN: 1943-7811 (Electronic) 1525-1578 (Linking).

(Links | BibTeX)

Bostock, S; Bryan, J

Radiotherapy-induced skin reactions: assessment and management (Journal Article)

Br J Nurs, 25 (4), pp. S18, S20-4, 2016, ISSN: 0966-0461 (Print) 0966-0461 (Linking).

(Links | BibTeX)

Bryan, J; Redden, P; Traba, C

The mechanism of action of Russian propolis ethanol extracts against two antibiotic-resistant biofilm-forming bacteria (Journal Article)

Lett Appl Microbiol, 62 (2), pp. 192-8, 2016, ISSN: 1472-765X (Electronic) 0266-8254 (Linking).

(Links | BibTeX)

Carty, C I; Lee, A M; Wienandt, N A; Stevens, E L; Alves, D A; Browne, J A; Bryan, J; Ryan, E G; Cassidy, J P

Dermatosparaxis in two Limousin calves (Journal Article)

Ir Vet J, 69 , pp. 15, 2016, ISSN: 0368-0762 (Print) 0368-0762 (Linking).

(Links | BibTeX)

Chard, K; Lidman, M; McCollam, B; Bryan, J; Ananthakrishnan, R; Tuecke, S; Foster, I

Globus Nexus: A Platform-as-a-Service Provider of Research Identity, Profile, and Group Management (Journal Article)

Future Gener Comput Syst, 56 , pp. 571-583, 2016, ISSN: 0167-739X (Print) 0167-739X (Linking).

(Links | BibTeX)

Knight, A; Bryan, J; Murphy, K

Is the Mediterranean diet a feasible approach to preserving cognitive function and reducing risk of dementia for older adults in Western countries? New insights and future directions (Journal Article)

Ageing Res Rev, 25 , pp. 85-101, 2016, ISSN: 1872-9649 (Electronic) 1568-1637 (Linking).

(Links | BibTeX)

Knight, A; Bryan, J; Murphy, K

The Mediterranean diet and age-related cognitive functioning: A systematic review of study findings and neuropsychological assessment methodology (Journal Article)

Nutr Neurosci, pp. 1-20, 2016, ISSN: 1476-8305 (Electronic) 1028-415X (Linking).

(Links | BibTeX)

Knight, A; Bryan, J; Wilson, C; Hodgson, J M; Davis, C R; Murphy, K J

The Mediterranean Diet and Cognitive Function among Healthy Older Adults in a 6-Month Randomised Controlled Trial: The MedLey Study (Journal Article)

Nutrients, 8 (9), 2016, ISSN: 2072-6643 (Electronic) 2072-6643 (Linking).

(Links | BibTeX)

78 entries « 1 of 8 »