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Core Faculty

Dmitriy Shin, Ph.D.

Assistant Professor

Office: M251 Medical Science Building

Phone: 882-6940


Lab URL:

Home Department: Pathology and Anatomical Science

Concentration: Biomedical Informatics

Education: PhD, University of Missouri

Dr. Shin studies computational methods in biomedicine. He leads the Translational and Cancer Bioinformatics laboratory in MU School of Medicine, supervising PhD students and posdoctoral fellows. His primary research area is advanced computerized inference methods in personalized medicine. In his most recent work, Dr. Shin introduced the field of computational morphoproteomics in which visual patterns of protein expression from WSI immunohistochemical studies are used to infer complex interplay of signal transduction pathways to design effective combinatorial therapies for theranostics.
Dr. Shin has also been leading the Informatics/IT division of MU Pathology and Anatomical Sciences department for over 10 years. Under his leadership, new computer systems have been designed, implemented and supported, including ANA, flow cytometry, bone marrow, molecular pathology laboratory information systems and biorepository software, pathology digital dictation system, and high definition microscopy telepathology system. He has been involved in many aspects of PAS department operations, including outreach medical examiners services, and development of electronic teaching materials for anatomy and pathology education.
Recently Dr. Shin has established Whole Slide Image Analytics laboratory, which provides services for researchers and medical practitioners. WSI lab members are currently developing online WSI hematopathology and histology atlases in collaboration with Dr. Richard Hammer, MD , Dr. Donald Doll, MD and Dr. Krause, PhD.

Selected Publications


Shin, D; Kovalenko, M; Ersoy, I; Li, Y; Doll, D; Shyu, C R; Hammer, R

PathEdEx - Uncovering High-explanatory Visual Diagnostics Heuristics Using Digital Pathology and Multiscale Gaze Data (Journal Article)

J Pathol Inform, 8 , pp. 29, 2017, ISSN: 2229-5089 (Print).

(Links | BibTeX)


Thanintorn, N; Wang, J; Ersoy, I; Al-Taie, Z; Jiang, Y; Wang, D; Verma, M; Joshi, T; Hammer, R; Xu, D; Shin, D

Rdf Sketch Maps - Knowledge Complexity Reduction for Precision Medicine Analytics (Journal Article)

Pac Symp Biocomput, 21 , pp. 417-28, 2016, ISSN: 2335-6936 (Print).

(Links | BibTeX)


Shin, D; Rogatsky, E; Stoyanov, A

Simultaneous monitoring of multiple transitions in mass spectromic analyas impoves limit of detction for low abundance substances in complex biological samples (Journal Article)

Journal Chromatograph Separat Techniq, 4 (206), 2015.

(Links | BibTeX)


Chen, Z; Shin, D; Chen, S; Mikhail, K; Hadass, O; Tomlison, B N; Korkin, D; Shyu, C R; Cui, J; Anthony, D C; Gu, Z

Histological quantitation of brain injury using whole slide imaging: a pilot validation study in mice (Journal Article)

PLoS One, 9 (3), pp. e92133, 2014, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking).

(Links | BibTeX)

Shin, D; Arthur, G; Popescu, M; Korkin, D; Shyu, C R

Uncovering influence links in molecular knowledge networks to streamline personalized medicine (Journal Article)

J Biomed Inform, 52 , pp. 394-405, 2014, ISSN: 1532-0480 (Electronic) 1532-0464 (Linking).

(Links | BibTeX)


Hadass, O; Tomlinson, B N; Gooyit, M; Chen, S; Purdy, J J; Walker, J M; Zhang, C; Giritharan, A B; Purnell, W; Robinson, 2nd C R; Shin, D; Schroeder, V A; Suckow, M A; Simonyi, A; Sun, G Y; Mobashery, S; Cui, J; Chang, M; Gu, Z

Selective inhibition of matrix metalloproteinase-9 attenuates secondary damage resulting from severe traumatic brain injury (Journal Article)

PLoS One, 8 (10), pp. e76904, 2013, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking).

(Links | BibTeX)


Shin, D; Arthur, G; Caldwell, C; Popescu, M; Petruc, M; Diaz-Arias, A; Shyu, C R

A pathologist-in-the-loop IHC antibody test selection using the entropy-based probabilistic method (Journal Article)

J Pathol Inform, 3 , pp. 1, 2012, ISSN: 2153-3539 (Electronic).

(Links | BibTeX)