Skip to navigation Skip to content


Chi-Ren Shyu, Ph.D.

Professor & Director

Office: 241 Naka Hall

Phone: 882-9007


Lab URL:

Home Department: Electrical Engineering and Computer Science

Concentration: Bioinformatics, Health Informatics

Education: PhD, Purdue University

Chi-Ren Shyu received his MSEE and Ph.D. degrees in Electrical and Computer Engineering from Purdue University in 1994 and 1999, respectively. Upon completing one year of post-doctoral training at Purdue, he joined the Electrical Engineering and Computer Science Department at the University of Missouri-Columbia in October 2000. In addition to holding the Shumaker Endowed Professorship for Informatics, he is currently the Director of the MU Informatics Institute, a Ph.D. program in bioinformatics and health informatics.
As the founding director of the Medical and Biological Digital Library Research Lab, Dr. Shyu oversees the work of a crew of students on a variety of research projects in such areas as biomedical informatics, geospatial informatics, data mining, and computer vision. Project sponsors for his research include the National Science Foundation, the National Geospatial-Intelligence Agency, the National institute of Health, U.S. Department of Education, University of Missouri Research Board, University of Missouri- Columbia Research Council, and other organizations, both for-profit and non-profit.

Selected Publications

23 entries « 1 of 3 »


Sheets, L; Petroski, G F; Zhuang, Y; Phinney, M A; Ge, B; Parker, J C; Shyu, C R

Combining Contrast Mining with Logistic Regression To Predict Healthcare Utilization in a Managed Care Population (Journal Article)

Appl Clin Inform, 8 (2), pp. 430-446, 2017, ISSN: 1869-0327 (Electronic).

(Links | BibTeX)


Kuang, X; Dhroso, A; Han, J G; Shyu, C R; Korkin, D

DOMMINO 2.0: integrating structurally resolved protein-, RNA-, and DNA-mediated macromolecular interactions (Journal Article)

Database (Oxford), 2016 , 2016, ISSN: 1758-0463 (Electronic) 1758-0463 (Linking).

(Links | BibTeX)

Smith, N R; Rivera, L A; Dietrich, M; Shyu, C R; Page, M P; DeSouza, G N

Detection of Simulated Vocal Dysfunctions Using Complex sEMG Patterns (Journal Article)

IEEE J Biomed Health Inform, 20 (3), pp. 787-801, 2016, ISSN: 2168-2208 (Electronic) 2168-2194 (Linking).

(Links | BibTeX)


Chan, L W; Liu, Y; Chan, T; Law, H K; Wong, S C; Yeung, A P; Lo, K F; Yeung, S W; Kwok, K Y; Chan, W Y; Lau, T Y; Shyu, C R

PubMed-supported clinical term weighting approach for improving inter-patient similarity measure in diagnosis prediction (Journal Article)

BMC Med Inform Decis Mak, 15 , pp. 43, 2015, ISSN: 1472-6947 (Electronic) 1472-6947 (Linking).

(Links | BibTeX)

Chan, L W; Pang, B; Shyu, C R; Chan, T; Khong, P L

Genetic algorithm supported by graphical processing unit improves the exploration of effective connectivity in functional brain imaging (Journal Article)

Front Comput Neurosci, 9 , pp. 50, 2015, ISSN: 1662-5188 (Linking).

(Links | BibTeX)

Ibraheem, F; Gaffoor, I; Tan, Q; Shyu, C R; Chopra, S

A sorghum MYB transcription factor induces 3-deoxyanthocyanidins and enhances resistance against leaf blights in maize (Journal Article)

Molecules, 20 (2), pp. 2388-404, 2015, ISSN: 1420-3049 (Electronic) 1420-3049 (Linking).

(Links | BibTeX)

Pang, B; Schlessman, D; Kuang, X; Zhao, N; Shyu, D; Korkin, D; Shyu, C R

An Integrated Approach to Sequence-Independent Local Alignment of Protein Binding Sites (Journal Article)

IEEE/ACM Trans Comput Biol Bioinform, 12 (2), pp. 298-308, 2015, ISSN: 1557-9964 (Electronic) 1545-5963 (Linking).

(Links | BibTeX)

Tidhar, D; Armer, J M; Deutscher, D; Shyu, C R; Azuri, J; Madsen, R

Measurement Issues in Anthropometric Measures of Limb Volume Change in Persons at Risk for and Living with Lymphedema: A Reliability Study (Journal Article)

J Pers Med, 5 (4), pp. 341-53, 2015, ISSN: 2075-4426 (Linking).

(Links | BibTeX)


Chen, Z; Shin, D; Chen, S; Mikhail, K; Hadass, O; Tomlison, B N; Korkin, D; Shyu, C R; Cui, J; Anthony, D C; Gu, Z

Histological quantitation of brain injury using whole slide imaging: a pilot validation study in mice (Journal Article)

PLoS One, 9 (3), pp. e92133, 2014, ISSN: 1932-6203 (Electronic) 1932-6203 (Linking).

(Links | BibTeX)

Han, J G; Cao, H; Barb, A; Punyasena, S W; Jaramillo, C; Shyu, C R

A neotropical Miocene pollen database employing image-based search and semantic modeling (Journal Article)

Appl Plant Sci, 2 (8), 2014, ISSN: 2168-0450 (Linking).

(Links | BibTeX)

23 entries « 1 of 3 »