Office: 222D Dalton
Phone: (573) 882-6045
Lab URL: http://zoulab.dalton.missouri.edu/
Home Department: Physics and Astronomical Sciences
Education: PhD, University of California at San Diego
Protein-ligand interactions, Protein-protein interactions, Virtual database screening, Computer-aided drug design, Modeling of quantitative structure-function relationships of membrane proteins
FASEB MARC Program Travel Award for Poster/Oral Presenters (2002)
Postdoctoral Fellowship of American Heart Association (1994-95)
Tuition and Fee Scholarship, University of California, San Diego (1988)
Scholarship of China-US Physics Examination Application Program (CUSPEA) (1987)
First Prize Scholarship at Wuhan University, China (1983-87)
NSF CAREER Award: A computational approach to template-based structure selection for protein-protein interactions.(2010)
vol. 82:4 pp. 620–632
M Lensink, I Moal, P Bates, P Kastritis, A Melquiond, X Zou, Blind prediction of interfacial water positions in CAPRI, Proteins: Structure, Function, and Bioinformatics, 620–632, 2014.
vol. 77:2 pp. 222–234
J Xu, J Xie, C Yan, X Zou, D Ren, S Zhang, A chemical genetic approach demonstrates that MPK3/MPK6 activation and NADPH oxidase-mediated oxidative burst are two independent signaling events in plant immunity, The Plant Journal, 222–234, 2014.
vol. 289:8 pp. 4735–4742
M Li, S Chang, L Yang, J Shi, K McFarland, X Yang, A Moller, C Wang, X Zou, C Chi, others, Conopeptide Vt3. 1 preferentially inhibits BK potassium channels containing β4 subunits via electrostatic interactions, Journal of Biological Chemistry, 4735–4742, 2014.
vol. 35:12 pp. 932–943
S Grinter, X Zou, A Bayesian statistical approach of improving knowledge-based scoring functions for protein–ligand interactions, Journal of computational chemistry, 932–943, 2014.
vol. 81:11 pp. 1980-1987
R Moretti, S Fleishman, R Agius, M Torchala, P Bates, P Kastritis, J Rodrigues, M Trellet, A Bonvin, M Cui, M Rooman, D Gillis, Y Dehouck, I Moal, M Romero-Durana, L Perez-Cano, C Pallara, B Jimenez, J Fernandez-Recio, S Flores, M Pacella, K Praneeth Kilambi, J Gray, P Popov, S Grudinin, J Esquivel-Rodríguez, D Kihara, N Zhao, D Korkin, X Zhu, O Demerdash, J Mitchell, E Kanamori, Y Tsuchiya, H Nakamura, H Lee, H Park, C Seok, J Sarmiento, S Liang, S Teraguchi, D Standley, H Shimoyama, G Terashi, M Takeda-Shitaka, M Iwadate, H Umeyama, D Beglov, D Hall, D Kozakov, S Vajda, B Pierce, H Hwang, T Vreven, Z Weng, Y Huang, H Li, X Yang, X Ji, S Liu, Y Xiao, M Zacharias, S Qin, H Zhou, S Huang, X Zou, S Velankar, J Janin, S Wodak, D Baker, Community-wide evaluation of methods for predicting the effect of mutations on protein-protein interactions, Proteins, 1980-1987, 2013.
vol. 81:12 pp. 2183–2191
S Huang, C Yan, S Grinter, S Chang, L Jiang, X Zou, Inclusion of the orientational entropic effect and low-resolution experimental information for protein–protein docking in Critical Assessment of PRedicted Interactions (CAPRI), Proteins: Structure, Function, and Bioinformatics, 2183–2191, 2013.
vol. 53:8 pp. 1905-1914
S Grinter, C Yan, S Huang, L Jiang, X Zou, Automated large-scale file preparation, docking and scoring: Evaluation of ITScore and STScore using the 2012 Community Structure-Activity Resource Benchmark, Journal of Chemical Information and Modeling, 1905-1914, 2013.
vol. 116:22 pp. 6431–6438
T Yu, X Wang, J Sang, C Pan, X Zou, T Chen, X Zou, Influences of mutations on the electrostatic binding free energies of chloride ions in Escherichia coli ClC, The Journal of Physical Chemistry B, 6431–6438, 2012.
vol. 51:9 pp. 2097-2106
Keywords: Protein Binding, proteins, Crystallization, Ligands, Structure-Activity Relationship
S Huang, X Zou, Scoring and lessons learned with the CSAR benchmark using an improved iterative knowledge-based scoring function, Journal of Chemical Information and Modeling, 2097-2106, 2011.
vol. 51:9 pp. 2107-2114
Keywords: Models, Molecular, Ligands, binding sites
S Huang, X Zou, Construction and test of ligand decoy sets using MDock: Community structure-activity resource benchmarks for binding mode prediction, Journal of Chemical Information and Modeling, 2107-2114, 2011.
Keywords: computational biology, Algorithms, Databases, Protein, Molecular Dynamics Simulation, Protein Conformation, Protein Folding, Thermodynamics, proteins
S Huang, X Zou, Statistical mechanics-based method to extract atomic distance-dependent potentials from protein structures, Proteins, 2648-2661, 2011.
vol. 29:6 pp. 795-799
Keywords: Antineoplastic Agents, Aza Compounds, Benzophenones, Bicyclo Compounds, Heterocyclic, Breast Neoplasms, Cell Line, Tumor, Cell Survival, DNA, Enzyme Inhibitors, Female, Humans, Intramolecular Transferases, Models, Molecular, Protein Binding, Protein Interaction Domains and Motifs, Tumor Suppressor Protein p53, computational biology, drug discovery
S Grinter, Y Liang, S Huang, S Hyder, X Zou, An inverse docking approach for identifying new potential anti-cancer targets, Journal of Molecular Graphics & Modelling, 795-799, 2011.
vol. 21:5 pp. 299-314
W Rockey, F Hernandez, S Huang, S Cao, C Howell, G Thomas, X Liu, N Lapteva, D Spencer, J McNamara, X Zou, S Chen, P Giangrande, Rational truncation of an RNA aptamer to prostate-specific membrane antigen using computational structural modeling, Nucleic Acid Therapeutics (Formerly Oligonucleotides), 299-314, 2011.
vol. 12:40 pp. 12899–12908
S Huang, S Grinter, X Zou, Scoring functions and their evaluation methods for protein–ligand docking: recent advances and future directions, Physical Chemistry Chemical Physics, 12899–12908, 2010.
vol. 113:35 pp. 11793–11799
H Liu, S Grinter, X Zou, Multiscale generalized born modeling of ligand binding energies for virtual database screening, The Journal of Physical Chemistry B, 11793–11799, 2009.